Trifluoroacetic acid → Trifluoroacetic acid

HRID 1867577ノート

反応式

HRID 1867577 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[NH:15]1[CH2:16][CH2:17][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:19][CH2:20]1.[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 46344059Tert-butyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

生成物 2

HCID 6422Trifluoroacetic acidHCID 130317571-(Piperidin-4-yl)imidazolidin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (0.5 mL) was added to a solution of 1-(1-t-butoxycarbonylpiperidin-4-yl)imidazolidin-2-one (30 mg, 0.11 mmol) in dichloromethane (2 mL) and the reaction stirred at room temperature for 5 h. The reaction was concentrated in vacuo to give the title compound as its trifluoroacetic acid salt (18 mg).

後処理

  1. concentrationThe reaction was concentrated in vacuo

出典と根拠

ORDレコード
ord-1d965ec6b349442796471c69f0c85d7a
出典データセット
uspto-grants-2009_12
特許番号
US07632832B2

反応ノート

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