Trifluoroacetic acid → Trifluoroacetic acid

HRID 1867579ノート

反応式

HRID 1867579 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[NH:15]1[CH2:16][CH2:17][CH:18]([N:21]2[CH2:25][CH2:24][CH2:2][NH:23][C:22]2=[O:26])[CH2:19][CH2:20]1.[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 46344059Tert-butyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

生成物 2

HCID 6422Trifluoroacetic acidHCID 155726661-(Piperidin-4-yl)-1,3-diazinan-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (0.5 mL) was added to a solution of 1-(1-t-butoxycarbonylpiperidin-4-yl)imidazolidin-2-one (20 mg, 0.07 mmol) in dichloromethane (2 mL) and the reaction stirred at room temperature overnight. The reaction was concentrated in vacuo to give the title compound as its trifluoroacetic acid salt (12 mg).

後処理

  1. concentrationThe reaction was concentrated in vacuo

出典と根拠

ORDレコード
ord-5b9695d05f5d46c5aa4c11c558682937
出典データセット
uspto-grants-2009_12
特許番号
US07632832B2

反応ノート

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