Trifluoroacetic acid → 2-Oxo-1-piperidin-4-yl-2,3-dihydro-1H-imidazole-4-carbonitrile
反応式
FC(F)(F)C(O)=O.[C:8]([C:10]1[NH:11][C:12](=[O:28])[N:13]([CH:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH:14]=1)#[N:9]>ClCCl>[O:28]=[C:12]1[NH:11][C:10]([C:8]#[N:9])=[CH:14][N:13]1[CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1参加物
4
実験手順
Trifluoroacetic acid (4 mL) was added to a solution of tert-butyl 4-(4-cyano-2-oxo-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate (25 mg, 0.086 mmol) in dichloromethane (6 mL). After 20 min, the reaction was concentrated to give the title compound. MS 193.3 (M+1)
後処理
- concentrationthe reaction was concentrated
出典と根拠
- ORDレコード
- ord-00b0c65137c74ce99ec0883b1ebbf94b
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07632832B2
反応ノート
読み込み中…