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Water → N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide

HRID 1867653
ノート
印刷プレビュー

反応式

HRID 1867653 の反応式
[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.C(N(CC)CC)C.Cl.[Cl:28][C:29]1[C:34]([C:35](Cl)=[O:36])=[CH:33][N:32]=[CH:31][CH:30]=1.O>O1CCCC1>[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:19]=[CH:18][C:16]([NH:17][C:35](=[O:36])[C:34]3[C:29]([Cl:28])=[CH:30][CH:31]=[N:32][CH:33]=3)=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 27641164-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}anilineHCID 231520084-Chloronicotinoyl chloride hydrochloride

生成物 1

HCID 23151884N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

A solution of 150 mg of 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)aniline and 116 mg of triethylamine in 5 mL of tetrahydrofuran was stirred with 100 mg of 4-chloronicotinoyl chloride hydrochloride for about 50 minutes, and after addition of water, the precipitated crystals were recovered by filtration. The recovered crystals were washed with ether and dried to 106 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide having a melting point of 178-180° C. (decomposition).

後処理

  1. filtrationthe precipitated crystals were recovered by filtration
  2. washThe recovered crystals were washed with ether
  3. dry with materialdried to 106 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide having a melting point of 178-180° C. (decomposition)

出典と根拠

ORDレコード
ord-afe8394e47b649088fd1799f755c126a
出典データセット
uspto-grants-2009_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07632865B2

反応ノート

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