1,1-Dichloroethane → 1-(3-Chloropyridin-2-yl)piperazine

HRID 1868010

反応式

HRID 1868010 の反応式
[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O.ClC(Cl)C>ClCCl>[Cl:1][C:2]1[C:3]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 63651,1-DichloroethaneHCID 6422Trifluoroacetic acid2 回HCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

生成物 1

HCID 114129441-(3-Chloropyridin-2-yl)piperazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give 1-(3-chloropyridin-2-yl)piperazine in quantitative yield (1.265 g).

後処理

  1. customReaction

出典と根拠

ORDレコード
ord-30b29d4f567642f38fcd9d67ddf87c72
出典データセット
uspto-grants-2009_12
特許番号
US07632838B2

関連ノート

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