Dichloromethane → 2,6-Bis(chloromethyl)-4-methylphenol

HRID 1868528ノート

反応式

HRID 1868528 の反応式
O[CH2:2][C:3]1[C:8]([OH:9])=[C:7](CO)[CH:6]=[C:5]([CH3:12])[CH:4]=1.O=S(Cl)[Cl:15].[CH2:17]([Cl:19])Cl>>[Cl:15][CH2:2][C:3]1[C:8]([OH:9])=[C:7]([CH2:17][Cl:19])[CH:6]=[C:5]([CH3:12])[CH:4]=1

参加物

4

反応物 3

HCID 6344DichloromethaneHCID 70392,6-Dimethylol-p-cresolHCID 24386Thionyl Chloride

生成物 1

HCID 221462,6-Bis(chloromethyl)-4-methylphenol

実験手順

2,6-Bis(hydroxymethyl)-p-cresol (0.6779 g, 4.03 mmol) was suspended in CH2Cl2 (10 ml), and to this suspension was added slowly SOCl2 (3 ml, 41.1 mmol) under cooling in an ice-bath, and the resulting mixture was stirred at room temperature for 18 hours. The color of the reaction solution turned yellow. After completion of the reaction, the solvent was removed by evaporation to give 2,6-bis(chloromethyl)-p-cresol.

後処理

  1. temperatureunder cooling in an ice-bath
  2. customAfter completion of the reaction
  3. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-80d1497d8d804bc585bc7e76c5feae3e
出典データセット
uspto-grants-2009_12
特許番号
US07635776B2

反応ノート

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