Water → bis(4-oxo-2-phenyl-4H-chromen-3-yl)terephthalate

HRID 1868535

反応式

HRID 1868535 の反応式
[OH:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:19](Cl)(=[O:29])[C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1.ClCCl.C(N([CH2:39][CH3:40])CC)C.[OH2:41]>>[C:19]([O:29][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:40]1[CH:39]=[CH:18][CH:13]=[CH:14][CH:15]=1)(=[O:41])[C:20]1[CH:28]=[CH:27][C:23]([C:24]([O:1][C:2]2[C:11](=[O:12])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[O:4][C:3]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[O:25])=[CH:22][CH:21]=1

参加物

6

反応物 5

HCID 962WaterHCID 6344DichloromethaneHCID 7488Terephthaloyl chlorideHCID 8471TriethylamineHCID 11349Flavonol

生成物 1

HCID 57983717bis(4-oxo-2-phenyl-4H-chromen-3-yl)terephthalate

実験手順

To the three-necked round bottom flask attached with reflux condenser, calcium chloride guard tube and nitrogen inlet, 3-hydroxy-2-phenyl-4H-chromen-4-one (0.59 g), terephthaloyl chloride (0.59 g) and dichloromethane (50 ml) were charged. Then triethyl amine (0.29 g) was charged and the reaction mixture was stirred at room temperature and monitored by thin layer chromatography (TLC). On completion of the reaction 10 ml water was added to the reaction mixture and the organic layer was separated. The organic layer was dried and evaporated under reduced pressure to give the product.

後処理

  1. temperaturewith reflux condenser, calcium chloride guard tube and nitrogen inlet
  2. additionwas added to the reaction mixture
  3. customthe organic layer was separated
  4. customThe organic layer was dried
  5. customevaporated under reduced pressure
  6. customto give the product

出典と根拠

ORDレコード
ord-27ddcee096b342339cace111a5ba3e6b
出典データセット
uspto-grants-2009_12
特許番号
US07635778B2

関連ノート

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