Potassium Hydroxide → 2-methyl-8H-indeno[2,1-b]thiophene
反応式
[CH3:1][C:2]1[S:6][C:5]2[C:7](=O)[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:4]=2[CH:3]=1.O.NN.[OH-].[K+]>C(O)COCCO.O>[CH3:1][C:2]1[S:6][C:5]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:4]=2[CH:3]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
A mixture of 6.83 g (0.034 mol) of 2-methyl-8H-indeno[2,1-b]thiophen-8-one and 9.1 mL (0.182 mol) of hydrazine monohydrate in 91 mL of diethylene glycol was stirred at 80° C. for 40 min and then refluxed for 1 h. The resulting mixture was cooled to room temperature, treated with a solution of 9.5 g (0.169 mol) of KOH in 34 mL water and then refluxed for 2 h. The resulting mixture was poured into 600 mL of water, the precipitate was filtered, washed 5 times with 200 mL of water and dried. Yield 5.8 g (92%).
後処理
- temperaturerefluxed for 1 h
- temperatureThe resulting mixture was cooled to room temperature
- temperaturerefluxed for 2 h
- filtrationthe precipitate was filtered
- washwashed 5 times with 200 mL of water
- customdried
出典と根拠
- ORDレコード
- ord-7330e21cf03146989d0f1f7327e1c232
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07635781B2
反応ノート
読み込み中…