3-Cyano-2-[3-(2-methoxy-phenyl)-propionylamino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2-acetoxy-ethyl ester → 3-Cyano-2-[3-(2-methoxy-phenyl)-propanoylamino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2-hydroxy-ethyl ester
反応式
C([O:4][CH2:5][CH2:6][O:7][C:8]([N:10]1[CH2:15][CH2:14][C:13]2[C:16]([C:32]#[N:33])=[C:17]([NH:19][C:20](=[O:31])[CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])[S:18][C:12]=2[CH2:11]1)=[O:9])(=O)C>[OH-].[Na+]>[OH:4][CH2:5][CH2:6][O:7][C:8]([N:10]1[CH2:15][CH2:14][C:13]2[C:16]([C:32]#[N:33])=[C:17]([NH:19][C:20](=[O:31])[CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])[S:18][C:12]=2[CH2:11]1)=[O:9]参加物
3
反応物 1
生成物 1
試薬・触媒・溶媒 1
実験手順
3-Cyano-2-[3-(2-methoxy-phenyl)-propionylamino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2-acetoxy-ethyl ester (Example 31) is stirred in 1N NaOH over night at room temperature. After acidification with aqueous HCl the precipitated product is filtered off and recristalized from ethanol.