Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester

HRID 18689

反応式

HRID 18689 の反応式
[CH3:1][O:2][C:3](=[O:6])[CH2:4]Br.[CH3:7][C:8]1[NH:9][CH:10]=[CH:11][N:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:6])[CH2:4][N:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH3:7]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 60984Methyl bromoacetate

生成物 1

HCID 28940036(2-Methyl-imidazol-1-yl)-acetic acid methyl ester収率 47%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.

後処理

  1. customAfter removal of the solvent the pure product
  2. customis obtained by flash chromatography in 47 to 78% yield

出典と根拠

ORDレコード
ord-0bedc00b6d0b4bcbacdd64180013cb6f
出典データセット
uspto-grants-2010_06
特許番号
US07741488B2

関連ノート

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