Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:6])[CH2:4]Br.[CH3:7][C:8]1[NH:9][CH:10]=[CH:11][N:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:6])[CH2:4][N:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH3:7]参加物
5
実験手順
4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.
後処理
- customAfter removal of the solvent the pure product
- customis obtained by flash chromatography in 47 to 78% yield
出典と根拠
- ORDレコード
- ord-0bedc00b6d0b4bcbacdd64180013cb6f
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741488B2
反応ノート
読み込み中…