Methylamine → HCID 68552631、化合物
反応式
CC1(C)[O:7][C:6](=O)[CH:5]([CH:9]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:10]2[C:18]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[NH:12][CH:11]=2)C(=O)O1.[CH3:27][NH2:28]>N1C=CC=CC=1>[CH3:27][NH:28][C:6](=[O:7])[CH2:5][CH:9]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:10]1[C:18]2[C:13](=[N:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1参加物
4
反応条件
- 温度
- 120 °C
実験手順
A sealed tube loaded with 2,2-dimethyl-5-[phenyl-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methyl]-[1,3]dioxane-4,6-dione (700 mg), methylamine (2M in THF, 3 ml) and pyridine (5 ml) was stirred at 120° C. for 2 hours. The reaction mixture was cooled to RT and partitioned between H2O and EtOAc. The organic layer was separated, dried over Na2SO4, filtered, concentrated, and purified via flash chromatography (hexane/EtOAc) affording N-Methyl-3-phenyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-propionamide.