Acetic Acid → 4-Amino-6-fluoroisoindolin-1-one

HRID 1869323ノート

反応式

HRID 1869323 の反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([N+:11]([O-])=O)[C:5]=1[CH2:14][N:15]=[N+]=[N-].C(O)(=O)C>C(O)C.[Pd]>[NH2:11][C:6]1[CH:7]=[C:8]([F:10])[CH:9]=[C:4]2[C:5]=1[CH2:14][NH:15][C:3]2=[O:2]

参加物

5

反応物 2

HCID 176Acetic AcidHCID 860442842-(Azidomethyl)-5-fluoro-3-nitrobenzoic Acid Methyl Ester

生成物 1

HCID 179850484-Amino-6-fluoroisoindolin-1-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1.86 g (7.32 mmol) of 2-(azidomethyl)-5-fluoro-3-nitrobenzoic acid methyl ester is added in 46 ml of ethanol and 3.4 ml of glacial acetic acid and mixed with 256.6 mg of Pd/C. After stirring overnight at room temperature under hydrogen atmosphere, the catalyst is suctioned off via a glass-fiber filter, and the filtrate is evaporated to the dry state. The residue, 1.18 mg (97.5%) of the desired compound, is further incorporated in crude form.

後処理

  1. filtrationfilter
  2. customthe filtrate is evaporated to the dry state

出典と根拠

ORDレコード
ord-3e55a77e528e4606a259b4b1e3967f63
出典データセット
uspto-grants-2009_12
特許番号
US07638515B2

反応ノート

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