化工社化工社 化学情報印刷レポート · 研究参考用
4-Methoxybenzenesulfonyl chloride → 5-Bromo-1-(4-methoxybenzenesulfonyl)-7-nitroindoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| 反応物 | 5-Bromo-7-nitroindoline | HCID 3018911 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 5-Bromo-1-(4-methoxybenzenesulfonyl)-7-nitroindoline | HCID 68612665 | 85% |
反応手順
A solution of 5-bromo-7-nitroindoline (5 g, 0.021 mol), 4-methoxyphenylsulfonyl chloride (6.36 g, 0.030 mol) in pyridine (10 ml) was stirred at 120° C. for 16 h. The reaction was quenched with water and extracted with CH2Cl2. The combined organic layer was dried over anhydrous MgSO4 and evaporated to give a residue that was chromatographed over silica gel (EtOAc:n-hexane=1:2) to afford compound 17, yield 85%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741495B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-c280e75b82b44a2190f44874a4c04dbc |
| 出典メモ | uspto-grants-2010_06 |