Benzimidazole → HCID 178495389、化合物

HRID 1869609ノート

反応式

HRID 1869609 の反応式
[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[NH:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].N1C2C=CC=CC=2NC=1.[OH-].[Na+:36]>C(OC(=O)C)C.N>[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[NH:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[N-:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].[Na+:36]

参加物

7

反応物 3

HCID 5798BenzimidazoleHCID 14798Sodium HydroxideHCID 178495390HCID 178495390、化合物2 回

生成物 2

HCID 178495389HCID 178495389、化合物HCID 178495390HCID 178495390、化合物

試薬・触媒・溶媒 2

HCID 222Ammonia溶媒HCID 8857Ethyl Acetate溶媒

実験手順

PCT Application PCT/GB2004/000064 and International Publication Number WO 2004/063188 A1, discloses the preparation of rabeprazole and benzimidazole type of compounds. Accordingly, rabeprazole base is prepared by oxidation using sodium hypohalites and isolated. Rabeprazole sodium is prepared by dissolving rabeprazole base in ethylacetate and methanolic ammonia mixture to which methanolic sodium hydroxide is added. The solvent is distilled and rabeprazole sodium is isolated from ethylacetate and n-heptane/n-hexane mixture.

後処理

  1. customisolated
  2. customRabeprazole sodium is prepared
  3. additionis added
  4. distillationThe solvent is distilled

出典と根拠

ORDレコード
ord-01389cdce6cb4e38ac51b1c46ea960b8
出典データセット
uspto-grants-2009_12
特許番号
US07638633B2

反応ノート

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