Methanol → HCID 10931849、化合物

反応式

[CH3:1][C:2]([C:6]([OH:8])=[O:7])([CH2:4][OH:5])[NH2:3].O=S(Cl)Cl.[CH3:13]O>>[CH3:13][O:7][C:6](=[O:8])[C:2]([NH2:3])([CH3:1])[CH2:4][OH:5]

参加物

反応物 3

HCID 887Methanol

HCID 24386Thionyl Chloride2 回

HCID 943092-Methylserine

生成物 1

HCID 10931849HCID 10931849、化合物

反応条件

温度: 0 °C

実験手順

A stirring solution of α-methyl-DL-Serine (1 g, 8.39 mmol) in MeOH (40 mL) in a flame dried round bottom flask under an inert atmosphere was cooled to 0° C. and SOCl2 (1.84 mL, 25.19 mmol) was slowly added. After addition of the SOCl2 was complete, the reaction mixture was stirred 12 hours at room temperature and then concentrated in vacuo to a white solid that was used directly in the next reaction.