Diethyl Ether → Methyl 2-fluoro-6-methoxybenzoate
反応式
[F:1][C:2]1[CH:3]=CC=[C:6](O)[C:7]=1C(O)=O.[C:12](=[O:15])([O-])[O-:13].[K+].[K+].[CH3:18]I.C[CH2:21][O:22][CH2:23][CH3:24]>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][CH:24]=[C:23]([O:22][CH3:21])[C:3]=1[C:12]([O:13][CH3:18])=[O:15]参加物
6
実験手順
To a solution of 6-fluorosalicylic acid (5.00 g) in dimethylformamide (50 ml) was added anhydrous potassium carbonate (6.00 g) and methyl iodide (6.0 ml) with stirring at room temperature, then followed by vigorous stirring at room temperature for 12 hours. After the completion of the reaction, the reaction mixture was diluted by ether, washed with water and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure, to give the title compound (5.80 g, 98%) as an oil.
後処理
- stirringby vigorous stirring at room temperature for 12 hours
- customAfter the completion of the reaction
- washwashed with water
- dry with materialdried over anhydrous sodium sulphate
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-935de1b4a8f04f918dc13c7dd07bd8d3
- 出典データセット
- uspto-grants-2000_08
- 特許番号
- US06096771
反応ノート
読み込み中…