Ammonia → HCID 18692760、化合物

HRID 1870680ノート

反応式

HRID 1870680 の反応式
S(=O)(=O)(O)O.Cl.[CH3:7][C:8]1[CH:17]=[C:11]2[N:12]=[CH:13][CH:14]=[C:15]([NH2:16])[N:10]2[N:9]=1.[N+:18]([O-])([OH:20])=[O:19].N>>[CH3:7][C:8]1[C:17]([N+:18]([O-:20])=[O:19])=[C:11]2[N:12]=[CH:13][CH:14]=[C:15]([NH2:16])[N:10]2[N:9]=1

参加物

5

反応物 4

HCID 222AmmoniaHCID 944Nitric AcidHCID 1118Sulfuric Acid2 回HCID 18692763HCID 18692763、化合物

生成物 1

HCID 18692760HCID 18692760、化合物収率 66%

実験手順

27 cc of 98% sulphuric acid were introduced into a 100 cc three-necked flask equipped with a magnetic stirrer, a thermometer and a condenser, after which 5.5 g of 2-methylpyrazolo[1,5-a]pyrimidin-7-ylamine hydrochloride were dissolved portionwise at 5° C. A mixture of 1.98 g of fuming nitric acid and 5 cc of 98% sulphuric acid was then added dropwise over 30 minutes. After reaction for 2 h 30', the medium was poured onto 200 cc of ice-cold water and neutralized with 122 g of 20% aqueous ammonia. The green precipitate which formed was filtered off. After drying under vacuum over phosphorus pentoxide, 3.8 g of 2-methyl-3-nitropyrazolo[1,5-a]pyrimidin-7-ylamine were obtained in the form of a green powder. (Crude yield=66%).

後処理

  1. customequipped with a magnetic stirrer
  2. additionwas then added dropwise over 30 minutes
  3. customAfter reaction for 2 h 30', the medium
  4. customThe green precipitate which formed
  5. filtrationwas filtered off
  6. dry with materialAfter drying under vacuum over phosphorus pentoxide

出典と根拠

ORDレコード
ord-f6d40ce0451444fca3494a2ffb49b597
出典データセット
uspto-grants-2000_08
特許番号
US06099593

反応ノート

読み込み中…