Potassium Hydroxide → 2-(2-Ethylphenyl)acetic acid
反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH:10]=[O:11])[CH3:2].[OH-:12].[K+]>CCO.O.[N+]([O-])([O-])=O.[Ag+]>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=[O:11])[CH3:2]参加物
6
反応条件
- 温度
- 0 °C
実験手順
To a solution of the crude (2-ethylphenyl)acetaldehyde in 20 ml of EtOH was added a solution of 2.29 g (13.52 mmol) of AgNO3 in 7.5 ml of water and a solution of 2.08 g (37.2 mmol) of KOH in 13 ml of water at 0° C. The reaction mixture was stirred at 0° C. for 2 h and was filtered to remove the solid. The filtrate was extracted with CH2Cl2 (20 ml×3) to remove impurity. The aqueous was acidified with 6N HCl to PH=1 and was extracted with CH2Cl2 (50 ml×3). The combined organic layers were dried MgSO4 and concentrated to give 2-ethylphenylacetic acid.
後処理
- customat 0° C
- filtrationwas filtered
- customto remove the solid
- extractionThe filtrate was extracted with CH2Cl2 (20 ml×3)
- customto remove impurity
- extractionwas extracted with CH2Cl2 (50 ml×3)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-58a7a8b3993e446dab193ff0b3e9974d
- 出典データセット
- uspto-grants-2000_08
- 特許番号
- US06100293
反応ノート
読み込み中…