Hydrochloric Acid → HCID 2778529、化合物
反応式
ClC1C=CC=CC=1C([O:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=O.[Cl-].[Al+3].[Cl-].[Cl-].Cl.[CH:23]([Cl:26])(Cl)Cl>>[Cl:26][C:23]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:7]([C:12]1[CH:11]=[C:10]([F:13])[CH:9]=[CH:8][C:7]=1[OH:6])=[O:6]参加物
5
実験手順
To a stirred solution of 2.5 g of compound A was added in small portions 1.47 g of powdered aluminum chloride at 130° C. and stirring was continued for another 1 hour. After cooling 1N HCl and chloroform was added to the reaction mixture and the organic layer was separated. The aqueous layer was extracted with chloroform. The combined organic layer was dried over magnesium sulfate and distilled to remove the solvent. The crude product thus obtained was crystallized from hexane to obtain 1.41 g of compound B. Yield: 56.3%.
後処理
- additionwas added to the reaction mixture
- customthe organic layer was separated
- extractionThe aqueous layer was extracted with chloroform
- dry with materialThe combined organic layer was dried over magnesium sulfate
- distillationdistilled
- customto remove the solvent
- customThe crude product thus obtained
- customwas crystallized from hexane
出典と根拠
- ORDレコード
- ord-91e0aecb40ce44f493b3ae70ab072de4
- 出典データセット
- uspto-grants-2000_08
- 特許番号
- USRE036832
反応ノート
読み込み中…