Water → 1-(Bromomethyl)-3-ethylbenzene

HRID 1871982

反応式

HRID 1871982 の反応式
P(Br)(Br)[Br:2].[CH2:5]([C:7]1[CH:8]=[C:9]([CH2:13]O)[CH:10]=[CH:11][CH:12]=1)[CH3:6].O>C1C=CC=CC=1>[Br:2][CH2:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([CH2:5][CH3:6])[CH:8]=1

参加物

5

反応物 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 104659(3-Ethylphenyl)methanol

生成物 1

HCID 220036561-(Bromomethyl)-3-ethylbenzene

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Phosphorous tribromide (5.3 ml) was added to a solution of the product from step (i) (7.6 g) in benzene (150 ml) at 0° C. After 3 hours, water (40 ml) was added and the mixture warmed to room temperature and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 2% ethyl acetate in isohexane. Yield 8.0 g.

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated
  4. customPurified by chromatography
  5. washeluting with 2% ethyl acetate in isohexane

出典と根拠

ORDレコード
ord-b501f9e1eb8544469e9e0de14223e35f
出典データセット
uspto-grants-2000_08
特許番号
US06107297

関連ノート

読み込み中…