Water → HCID 178435472、化合物

HRID 1871993ノート

反応式

HRID 1871993 の反応式
[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18](=[S:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].O.[C:28](=O)(O)[O-].[Na+].IC>C(O)C>[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:28])=[N:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 18689767HCID 18689767、化合物

生成物 1

HCID 178435472HCID 178435472、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The product of step (iii) (0.58 g) was dissolved in ethanol (30 ml) and water (5 ml) and treated with sodium bicarbonate(0.14 g) and iodomethane (0.2 ml) and stirred for 24 hours. The reaction mixture was partitioned between ethyl acetate and brine. The organic phase was dried (MgSO4) and solvent evaporated under reduced pressure. The residue was triturated with isohexane and filtered to give the product. Yield 0.41 g.

後処理

  1. customThe reaction mixture was partitioned between ethyl acetate and brine
  2. dry with materialThe organic phase was dried (MgSO4) and solvent
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with isohexane
  5. filtrationfiltered
  6. customto give the product

出典と根拠

ORDレコード
ord-fb51028a58cd4abbb2c17d5c242e8c7b
出典データセット
uspto-grants-2000_08
特許番号
US06107297

反応ノート

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