Methyl iodide → HCID 178503573、化合物

HRID 1871998ノート

反応式

HRID 1871998 の反応式
IC.[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19](=[S:25])[NH:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1.[C:28](=O)(O)[O-].[Na+]>C(O)C.O>[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19]([S:25][CH3:28])=[N:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 18689719HCID 18689719、化合物

生成物 1

HCID 178503573HCID 178503573、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Iodomethane (0.2 ml) was added to a stirred suspension of the product from step (i) (0.65 g) and sodium bicarbonate (0.4 g) in ethanol (15 ml) and water (4 ml). After stirring for 30 min, the reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water, dried (MgSO4) and evaporated under reduced pressure. The residue was triturated with ether and filtered. Yield 0.49 g.

後処理

  1. washthe reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with ether
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-19a02dd9780f4f77a7f4c8e0c691c1ba
出典データセット
uspto-grants-2000_08
特許番号
US06107297

反応ノート

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