Methylamine hydrochloride → (S)-(1-Methylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester

HRID 1872123

反応式

HRID 1872123 の反応式
Cl.[CH3:2][NH2:3].[CH3:4][C:5]([O:8][C:9]([NH:11][CH:12]([C:19]([OH:21])=O)[CH2:13][C:14]1[N:18]=[CH:17][S:16][CH:15]=1)=[O:10])([CH3:7])[CH3:6]>>[C:5]([O:8][C:9]([NH:11][C@@H:12]([CH2:13][C:14]1[N:18]=[CH:17][S:16][CH:15]=1)[C:19]([NH:3][CH3:2])=[O:21])=[O:10])([CH3:4])([CH3:6])[CH3:7]

参加物

3

反応物 2

HCID 6364545Methylamine hydrochlorideHCID 145403222-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid

生成物 1

HCID 22850398(S)-(1-Methylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester

実験手順

Methylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, acid wash omitted) and the product used without further purification. Yield, 250 mg, 88%.

後処理

  1. customthe product used without further purification
  2. customYield

出典と根拠

ORDレコード
ord-90522270a7bc4643827350fc855ef981
出典データセット
uspto-grants-2000_08
特許番号
US06107329

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