Methyl formate → 5-Diethylphosphono-2-thiophenecarboxaldehyde

HRID 1872511ノート

反応式

HRID 1872511 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[P:6]([O:11][CH2:12][CH3:13])(=[O:10])[O:7][CH2:8][CH3:9].[Li+].CC([N-]C(C)C)C.[CH:22](OC)=[O:23]>O1CCCC1>[CH2:12]([O:11][P:6]([C:2]1[S:1][C:5]([CH:22]=[O:23])=[CH:4][CH:3]=1)([O:7][CH2:8][CH3:9])=[O:10])[CH3:13]

参加物

5

反応物 3

HCID 7865Methyl formateHCID 2724682Lithium diisopropylamideHCID 42543912-Diethylphosphonothiophene

生成物 1

HCID 222749525-Diethylphosphono-2-thiophenecarboxaldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution 1.0 mmol of diethyl 2-thiophenephosphonate in tetrahydrofuran was treated with 1.12 mmol LDA at -78° C. for 20 min. 1.5 mmol methyl formate was added and the reaction was stirred for 1 hr. Extraction and chromotagraphy gave 5-diethylphosphono-2-thiophenecarboxaldehyde as a clear yellow oil.

後処理

  1. extractionExtraction and chromotagraphy

出典と根拠

ORDレコード
ord-de713f35154e4bdf87aef38d795ab539
出典データセット
uspto-grants-2000_08
特許番号
US06110903

反応ノート

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