Hydrogen Bromide → 5-Bromo-5-(4'-phenoxyphenyl)barbituric acid

HRID 1872583ノート

反応式

HRID 1872583 の反応式
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[C:19](=[O:20])[NH:18][C:17](=[O:21])[NH:16][C:15]2=[O:22])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BrH:23].BrBr>O>[Br:23][C:14]1([C:11]2[CH:10]=[CH:9][C:8]([O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:13][CH:12]=2)[C:15](=[O:22])[NH:16][C:17](=[O:21])[NH:18][C:19]1=[O:20]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 24408Bromine2 回HCID 116737785-(4-Phenoxyphenyl)-1,3-diazinane-2,4,6-trione

生成物 1

HCID 227322335-Bromo-5-(4'-phenoxyphenyl)barbituric acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

To a suspension of 5-(4'-phenoxyphenyl)barbituric acid (48 mg)in 0.23 ml of water, cooled at 0° C. and under stirring, are added 23 μl of 48% hydrobromic acid and successively 9 μl of bromine. After 2 hours at room temperature additional 9 μl of bromine are added and stirring is continued for 2 hours. The suspended solid is then filtered and washed with water, to give, after drying under vacuum at 60° C., 57 mg of the product, m.p. 125-127° C.

後処理

  1. stirringstirring
  2. filtrationThe suspended solid is then filtered
  3. washwashed with water
  4. customto give
  5. customafter drying under vacuum at 60° C.

出典と根拠

ORDレコード
ord-4605dd353cc443de858531ffca472627
出典データセット
uspto-grants-2000_08
特許番号
US06110924

反応ノート

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