HCID 18391989、化合物 → (R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyran

HRID 1872756ノート

反応式

HRID 1872756 の反応式
C([N:8]1[CH2:12][CH2:11][C@@H:10]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][O:15]2)[CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].CO>[O:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]1[O:13][C@@H:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

参加物

4

反応物 1

HCID 18391989HCID 18391989、化合物

生成物 1

HCID 18392016(R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyran収率 122.8%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A mixture of 1-benzyl-3-(R)-tetrahydropyranyloxypyrrolidine (8.78 g, 27.3 mmol) and Pearlman's catalyst (3.50 g) in MeOH (100 ml) was stirred under hydrogen atmosphere at rt for 4 h. After removal of the catalyst by Celite filtration, the filtrate was concentrated to give 5.74 g of clear light brown oil. This was used for the next reaction without purification.

後処理

  1. customAfter removal of the catalyst
  2. filtrationby Celite filtration
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-0dc481014de54bd2ae67a0767e3883f4
出典データセット
uspto-grants-2000_08
特許番号
US06110947

反応ノート

読み込み中…