Metronidazole → 2-(2-Methyl-5-nitro-1-imidazolyl)ethyl methanesulfonate
反応式
[CH3:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>N1C=CC=CC=1>[CH3:13][S:14]([O:9][CH2:8][CH2:7][N:6]1[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=[C:2]1[CH3:1])(=[O:16])=[O:15]参加物
4
実験手順
Metronidazole (5.0 g, 29.2 mmol) was dissolved in pyridine (10 ml), and a pyridine solution (10 ml) of methanesulfonyl chloride (3.5 g, 30.7 mmol) was added dropwise to the solution. After the mixture was stirred at room temperature for 5 hours, the solvent was distilled off under reduced pressure, and the residue was washed with water-ethanol and dried to obtain 6.4 g of the title compound.
後処理
- distillationthe solvent was distilled off under reduced pressure
- washthe residue was washed with water-ethanol
- customdried
出典と根拠
- ORDレコード
- ord-9ec146d9d4784dbd95530cabd85e2f32
- 出典データセット
- uspto-grants-2000_08
- 特許番号
- US06110967
反応ノート
読み込み中…