Pyrrolidine → HCID 86623311、化合物

HRID 1873495ノート

反応式

HRID 1873495 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].N1CCCC1.CO[CH:25](OC)[N:26]([CH3:28])[CH3:27]>C1(C)C=CC=CC=1>[CH3:25][N:26]([CH3:28])/[CH:27]=[CH:1]/[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:13])([F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16]

参加物

5

反応物 3

HCID 31268PyrrolidineHCID 78373Dimethylformamide dimethyl acetalHCID 542079941-Methyl-2-nitro-4-(pentafluoroethyl)benzene

生成物 1

HCID 86623311HCID 86623311、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 1-methyl-2-nitro-4-(perfluoroethyl)benzene (10.0 g, 39.2 mmol) and pyrollidine (2.79 g, 39.2 mmol) in toluene (250 mL) was added dimethyl formamide dimethyl acetal (4.96 g, 39.2 mmol). The mixture was heated to reflux for 16 hours. After cooling to room temperature the mixture was concentrated under vacuum and the resulting oil was immediately used in the next reaction.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 16 hours
  3. concentrationwas concentrated under vacuum
  4. customthe resulting oil was immediately used in the next reaction

出典と根拠

ORDレコード
ord-7f08ced6bb6242a9a33fa4354e92e376
出典データセット
uspto-grants-2012_11
特許番号
US08304407B2

反応ノート

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