Hydrochloric Acid → HCID 66916241、化合物

HRID 1873695ノート

反応式

HRID 1873695 の反応式
[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([C:17]([O:19]C)=[O:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[C:4]([F:25])[CH:3]=1.CO.[OH-].[Na+].Cl>O>[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([C:17]([OH:19])=[O:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[C:4]([F:25])[CH:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 66916282Methyl 4-(4-amino-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylate

生成物 1

HCID 66916241HCID 66916241、化合物収率 90%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Compound 39b (1.0 g) was added to methanol (10 mL), and 4M aqueous sodium hydroxide (650 μL) and water (400 μL) were further added thereto, followed by stirring at room temperature for 2 hours. After completion of reaction, 6N aqueous hydrochloric acid was added to the reaction mixture, to thereby adjust the pH to 3, and the precipitate was filtrated, whereby compound 39c was yielded (862 mg, yield: 90%).

後処理

  1. additionwere further added
  2. additionwas added to the reaction mixture
  3. filtrationthe precipitate was filtrated

出典と根拠

ORDレコード
ord-d7d62e3529aa402381a804b121bcb24f
出典データセット
uspto-grants-2012_11
特許番号
US08304427B2

反応ノート

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