Malonic Acid → HCID 68714384、化合物

反応式

[CH3:1][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[S:5][C:6]=1[CH:7]=O.C(O)(=O)[CH2:16][C:17]([OH:19])=[O:18].N1CCCCC1>N1C=CC=CC=1>[CH3:1][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[S:5][C:6]=1[CH:7]=[CH:16][C:17]([OH:19])=[O:18]

参加物

反応条件

温度: 100 °C

実験手順

A mixture of 300 mg (1.47 mmol) of 4-methyl-2-phenyl-thiazole-5-carbaldehyde, 169 mg (1.62 mmol) of malonic acid and 880 mg (10.33 mmol) of piperidine in 10 ml of pyridine was stirred at 90° C. for 5 h and at 100° C. for 6 h. After concentration, the residue was treated with a sodium hydrogencarbonate solution and ethyl acetate. The aqueous phase was separated and acidified. The precipitated product was filtered off with suction and dried. Yield: 260 mg.