Dimethyl Sulfoxide → 2-(Cyclopropylsulfonyl)-6-(trifluoromethyl)nicotinic acid

温度

120 °C

To a 100 ml round bottom flask was loaded magnesium bromide cyclopropanesulfinate (928 mg, 4.43 mmol), 2-chloro-6-(trifluoromethyl)nicotinic acid (250 mg, 1.11 mmol), CuI (844 mg, 4.43 mmol), NaOH (44.3 mg, 1.11 mmol), 20 ml dimethyl sulfoxide and 4 ml water. The resulting reaction mixture was flushed with nitrogen gas and heated at 120° C. for 18 hr. After cooling down to room temperature, the reaction mixture was diluted with 60 ml ethyl acetate and 60 ml water. It was filtered through a pad of celite, which was then rinsed with 20 ml ethyl acetate. The layers were separated from filtrates, and the organics were dried over sodium sulfate, filtered and concentrated. The residue was purified on reverse phase column eluted with water/acetonitrile gradient solvent to give desired product was white solid (152 mg, 0.52 mmol).

1. customTo a 100 ml round bottom flask was loaded
2. customThe resulting reaction mixture
3. customwas flushed with nitrogen gas
4. temperatureAfter cooling down to room temperature
5. additionthe reaction mixture was diluted with 60 ml ethyl acetate and 60 ml water
6. filtrationIt was filtered through a pad of celite, which
7. washwas then rinsed with 20 ml ethyl acetate
8. customThe layers were separated from filtrates
9. dry with materialthe organics were dried over sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated
12. customThe residue was purified on reverse phase column
13. washeluted with water/acetonitrile gradient solvent

ORDレコード

ord-50c9c996c5624630b85767311121f687

出典データセット

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08304434B2