2,4-Dichloro-1-(1-methoxy-2-nitro-propyl)-benzene → 1-(2,4-Dichlorophenyl)-1-methoxypropan-2-amine
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([O:15][CH3:16])[CH:10]([N+:12]([O-])=O)[CH3:11]>C1COCC1.[Ni].CCO>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([O:15][CH3:16])[CH:10]([NH2:12])[CH3:11]参加物
4
実験手順
2,4-dichloro-1-(1-methoxy-2-nitro-propyl)-benzene (132.2 g, 0.500 mol), was dissolved in THF (3.6 l). The solution was deaerated, RaNi-EtOH (133 g) catalyst was added, and the mixture was hydrogenated at 50 bar at ambient temperature for 23 hours. The catalyst was removed by filtration and the solvent was removed under reduced pressure. 117.1 g (100% of theory) of 2-(2,4-dichlorophenyl)-2-methoxy-1-methyl-ethylamine (compound Z1.14) was obtained in the form of a colourless oil as a mixture of diastereomeres.
後処理
- customThe catalyst was removed by filtration
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-b17ba39f1a224e61907c0bb15c8992e0
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08304444B2
反応ノート
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