Triethylamine → N-(3-hydroxyphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 1874378

反応式

HRID 1874378 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[CH3:16][N:17]1[C:21]([C:22](Cl)=[O:23])=[CH:20][C:19]([CH3:25])=[N:18]1>O1CCCC1>[OH:8][C:4]1[CH:3]=[C:2]([NH:1][C:22]([C:21]2[N:17]([CH3:16])[N:18]=[C:19]([CH3:25])[CH:20]=2)=[O:23])[CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 115683-AminophenolHCID 27362992,5-Dimethyl-2H-pyrazole-3-carbonyl chloride

生成物 1

HCID 19481482N-(3-hydroxyphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide収率 90%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In the same manner as in Reference Example 11 and using 3-aminophenol (2.11 g, 19.3 mmol), triethylamine (2.81 mL, 20.3 mmol), 1,3-dimethyl-1H-pyrazole-5-carbonyl chloride (3.07 g, 19.4 mmol) and tetrahydrofuran (30 mL) as starting materials, the title compound (4.00 g, 90%) was obtained as a white solid.

出典と根拠

ORDレコード
ord-e5a3316baa474928906f4985f5c44ec6
出典データセット
uspto-grants-2012_11
特許番号
US08304557B2

関連ノート

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