Dimethylformamide → Methyl 3-chloro-5-(chlorocarbonyl)-1H-pyrrole-2-carboxylate

HRID 1874963ノート

反応式

HRID 1874963 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[Cl:7][C:8]1[CH:9]=C(C(O)=O)[NH:11][C:12]=1[C:13]([O:15][CH3:16])=[O:14].CN(C=O)C>C(Cl)Cl>[Cl:7][C:8]1[CH:9]=[C:1]([C:2]([Cl:4])=[O:3])[NH:11][C:12]=1[C:13]([O:15][CH3:16])=[O:14]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 684860074-Chloro-5-[(methyloxy)carbonyl]-1H-pyrrole-2-carboxylic acid

生成物 1

HCID 86644903Methyl 3-chloro-5-(chlorocarbonyl)-1H-pyrrole-2-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Oxalyl chloride (0.430 mL, 4.91 mmol) was added to a solution of 4-chloro-5-[(methyloxy)carbonyl]-1H-pyrrole-2-carboxylic acid (0.500 g, 2.45 mmol) in DCM (50 mL). DMF (9.51 μl, 0.123 mmol) was added to the reaction mixture and the resulting suspension was stirred overnight. The solvent was evaporated to afford the title compound as a crude product (0.804 g) which was used with no further purification. 1H NMR (400 MHz, CDCl3) δ ppm 11.02 (s, 1H), 7.11 (d, 1H), 3.97 (s, 3H).

後処理

  1. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-c85082ad817640dca3439079bacee753
出典データセット
uspto-grants-2012_11
特許番号
US08304419B2

反応ノート

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