F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.[Cl-].FC(F)(F)C(O)=O.[NH2:36][C:37]1[CH:38]=[C:39]2[C:43](=[CH:44][CH:45]=1)[NH:42][C:41]([C:46]([NH:48][CH2:49][C:50]1[CH:55]=[CH:54][C:53]([Cl:56])=[C:52]([O:57][C:58]3[CH:63]=[C:62]([C:64]#[N:65])[CH:61]=[C:60]([Cl:66])[CH:59]=3)[C:51]=1[F:67])=[O:47])=[CH:40]2.[CH3:68][O:69][CH2:70][CH2:71][O:72][CH2:73][CH2:74][O:75][CH2:76][C:77](O)=[O:78].C(N(C(C)C)CC)(C)C>CN(C=O)C.C(OCC)(=O)C.O>[Cl:56][C:53]1[CH:54]=[CH:55][C:50]([CH2:49][NH:48][C:46]([C:41]2[NH:42][C:43]3[C:39]([CH:40]=2)=[CH:38][C:37]([NH:36][C:77](=[O:78])[CH2:76][O:75][CH2:74][CH2:73][O:72][CH2:71][CH2:70][O:69][CH3:68])=[CH:45][CH:44]=3)=[O:47])=[C:51]([F:67])[C:52]=1[O:57][C:58]1[CH:63]=[C:62]([C:64]#[N:65])[CH:61]=[C:60]([Cl:66])[CH:59]=1BOP chloride (0.079 g, 0.309 mmol) was added to a solution of 5-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate (0.060 g, 0.103 mmol), [(2-{[2-(methyloxy)ethyl]oxy}ethyl)oxy]acetic acid (0.016 mL, 0.103 mmol) and diisopropylethylamine (0.090 mL, 0.514 mmol) in DMF (1 mL). The mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with ethyl acetate and water. The organic layer was washed with water, dried over sodium sulfate and concentrated. The residue was purified by reverse phase HPLC (acetonitrile:water with 0.1% trifluoroacetic acid) to give the title compound (0.027 g, 42%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.54 (s, 1H), 9.39 (s, 1H), 8.97 (t, 1H), 7.92 (s, 1H), 7.78 (s, 1H), 7.49 (d, 1H), 7.46 (s, 1H), 7.42-7.45 (m, 1H), 7.33-7.40 (m, 1H), 7.31 (s, 2H), 7.09 (d, 1H), 4.53 (d, 2H), 4.02 (s, 2H), 3.61-3.66 (m, 2H), 3.56-3.60 (m, 2H), 3.53 (dd, 2H), 3.38-3.44 (m, 2H), 3.19 (s, 3H). ES MS: m/z 629 (M+1).
読み込み中…