Chlorosuccinimide → HCID 178454347、化合物

HRID 1875063ノート

反応式

HRID 1875063 の反応式
[Cl:1]N1C(=O)CCC1=O.[CH3:9][C:10]([O:13][C:14]([N:16]([C:24]1[NH:25][CH:26]=[C:27]([CH:29]=[O:30])[N:28]=1)[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:15])([CH3:12])[CH3:11]>C(#N)C>[CH3:12][C:10]([O:13][C:14]([N:16]([C:24]1[NH:28][C:27]([CH:29]=[O:30])=[C:26]([Cl:1])[N:25]=1)[C:17]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:18])=[O:15])([CH3:9])[CH3:11]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 178454349HCID 178454349、化合物

生成物 1

HCID 178454347HCID 178454347、化合物収率 11.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

N-Chlorosuccinimide (0.346 g, 2.59 mmol) was added to a suspension of bis(1,1-dimethylethyl)(4-formyl-1H-imidazol-2-yl)imidodicarbonate (0.672 g, 2.158 mmol) in acetonitrile (10 mL). The mixture was heated at 60° C. for 2 hrs. The solvent was evaporated. Chromatography of the residue with ethyl acetate:hexane gave the title compound (0.086 g, 11%) as a white solid. 1H NMR (400 MHz, chloroform-d) δ ppm 10.38-10.79 (m, 1H), 9.6 (s, 1H), 1.52 (s, 18H). ES MS: m/z 345

後処理

  1. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-629ea1e83bdc44b1b8ab43a9d88aa9dd
出典データセット
uspto-grants-2012_11
特許番号
US08304419B2

反応ノート

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