Trifluoroacetic acid → 3-{[3-(Aminomethyl)-6-(difluoromethyl)-2-fluorophenyl]oxy}-5-chlorobenzonitrile

HRID 1875104ノート

反応式

HRID 1875104 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([O:10][C:11]2[C:12]([F:29])=[C:13]([CH2:20][NH:21]C(=O)OC(C)(C)C)[CH:14]=[CH:15][C:16]=2[CH:17]([F:19])[F:18])[CH:5]=[C:6]([C:8]#[N:9])[CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[NH2:21][CH2:20][C:13]1[C:12]([F:29])=[C:11]([O:10][C:4]2[CH:5]=[C:6]([CH:7]=[C:2]([Cl:1])[CH:3]=2)[C:8]#[N:9])[C:16]([CH:17]([F:19])[F:18])=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 867616531,1-Dimethylethyl {[3-[(3-chloro-5-cyanophenyl)oxy]-4-(difluoromethyl)-2-fluorophenyl]methyl}carbamate

生成物 1

HCID 684803913-{[3-(Aminomethyl)-6-(difluoromethyl)-2-fluorophenyl]oxy}-5-chlorobenzonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1,1-dimethylethyl {[3-[(3-chloro-5-cyanophenyl)oxy]-4-(difluoromethyl)-2-fluorophenyl]methyl}carbamate (0.152 g, 0.356 mmol) and TFA (1.372 ml, 17.81 mmol) in dichloromethane (10 ml) was stirred for 16 h at RT under an atmosphere of nitrogen. The solution was concentrated under vacuum to give the title compound as an orange oil that was used without further purification. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.40-7.52 (m, 2H), 7.31 (s, 1H), 7.23-7.26 (m, 1H), 6.89 (s, 1H), 6.74 (t, 1H), 4.19 (br. s., 2H).

後処理

  1. concentrationThe solution was concentrated under vacuum

出典と根拠

ORDレコード
ord-01af6f8aff2244a7bfa9836b5b2c51ce
出典データセット
uspto-grants-2012_11
特許番号
US08304419B2

反応ノート

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