Hydrochloric Acid → HCID 68590313、化合物
反応式
[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]([N:14]3[CH2:18][CH2:17][C@@H:16]([NH:19]C(=O)OC(C)(C)C)[CH2:15]3)=[O:13])[CH:8]=2)[CH2:3]1.Cl>C1COCC1>[NH2:19][C@@H:16]1[CH2:17][CH2:18][N:14]([C:12]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[CH2:3][N:2]([CH3:1])[CH2:11][CH2:10]3)=[O:13])[CH2:15]1参加物
4
実験手順
1.4 g (3.8 mmol) tert. Butyl (R)-[1-(2-methyl-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-pyrrolidin-3-yl]-carbamate are dissolved in 5 ml THF and slowly combined with 9.5 ml hydrochloric acid (4 M in 1,4-dioxane). The mixture is stirred for two hours, then concentrated down to ⅔ of its volume and the crude product is filtered off as a precipitate, which is then purified by RP-HPLC (eluant: gradient ammonia/acetonitrile).
後処理
- concentrationconcentrated down