Sodium borohydride → HCID 21821162、化合物
反応式
[I-].[CH3:2][N+:3]1[CH2:8][CH2:7][C:6]2[CH:9]=[CH:10][S:11][C:5]=2[C:4]=1[CH3:12].[BH4-].[Na+]>CO>[CH3:2][N:3]1[CH2:8][CH2:7][C:6]2[CH:9]=[CH:10][S:11][C:5]=2[CH:4]1[CH3:12]参加物
4
実験手順
A mixture of 7.2 g (24 mmol) 6,7-dimethyl-4,5-dihydro-thieno[2,3-c]pyridinium iodide and 80 ml of methanol is mixed batchwise 1.87 g (49 mmol) NaBH4 while cooling with an ice bath (vigorous release of gas). The mixture is stirred for another 1.5 h, concentrated, mixed with sat. NaHCO3 solution and extracted 3× with methylene chloride. The organic phases are dried on NaSO4, filtered and concentrated.
後処理
- temperaturewhile cooling with an ice bath (vigorous release of gas)
- concentrationconcentrated
- additionmixed with sat. NaHCO3 solution
- extractionextracted 3× with methylene chloride
- customThe organic phases are dried on NaSO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-12e7451a4b9d44f4b2ca88fcf1719d21
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08309542B2
反応ノート
読み込み中…