Sodium Sulfate → 2-(2-Aminopropyl)thiophene
反応式
[N+:1]([C:4]([CH3:11])=[CH:5][C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)([O-])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[CH3:11][CH:4]([NH2:1])[CH2:5][C:6]1[S:7][CH:8]=[CH:9][CH:10]=1参加物
5
実験手順
A solution of 3.7 g (21.9 mmol) 2-(2-nitro-propenyl)-thiophene in 50 ml THF is added dropwise to a suspension of 4.1 g (109.3 mmol) lithium aluminium hydride in 150 ml THF. After the addition has ended the mixture is refluxed. After 1.5 hours it is cooled to RT and stirred for another 16 hours. Then the mixture is slowly combined with 10 ml sat. sodium sulphate solution and filtered through Celite. The filtrate thus obtained is evaporated down i. vac.
後処理
- additionAfter the addition
- temperatureis refluxed
- filtrationfiltered through Celite
- customThe filtrate thus obtained
- customis evaporated down i
出典と根拠
- ORDレコード
- ord-5dccfa5efd51411fbe1ff5834ec936bc
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08309542B2
反応ノート
読み込み中…