Thionyl Chloride → Methyl 4-chlorocinnoline-3-carboxylate

反応式

S(Cl)([Cl:3])=O.O[C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[N:8][C:7]=1[C:16]([O:18][CH3:19])=[O:17]>>[Cl:3][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[N:8][C:7]=1[C:16]([O:18][CH3:19])=[O:17]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 178499158HCID 178499158、化合物

生成物 1

HCID 20187472Methyl 4-chlorocinnoline-3-carboxylate

実験手順

Thionyl chloride (8.15 g, 5 ml) was added dropwise under inert atmosphere to methyl 4-hydroxycinnoline-3-carboxylate (0.50 g, 2.45 mmol). The mixture was heated to reflux for 1.5 h, cooled to room temperature and excess thionyl chloride was removed under vacuum. Toluene (5 ml) was added to the residue. The mixture was stirred at room temperature overnight. The solids were collected by filtration and dried under vacuum. The title compound was isolated as a brown solid (248 mg, 1.11 mmol, 45%). LCMS: m/z 223 [M+H]+.

後処理

temperatureThe mixture was heated
temperatureto reflux for 1.5 h
customexcess thionyl chloride was removed under vacuum
additionToluene (5 ml) was added to the residue
filtrationThe solids were collected by filtration
customdried under vacuum

出典と根拠

ORDレコード: ord-7a68a5a8db6e467db81839c9be13058d
出典データセット: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08309552B2

反応ノート

読み込み中…

参加物