Methyl iodide → (2-Chloro-quinazolin-4-yl)-(2-methoxy-phenyl)-methyl-amine

反応式

[Cl:1][C:2]1[N:11]=[C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:21]I>>[Cl:1][C:2]1[N:11]=[C:10]([N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[CH3:21])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

反応物 2

HCID 6328Methyl iodide

HCID 226927222-Chloro-N-(2-methoxyphenyl)quinazolin-4-amine

生成物 1

HCID 11266548(2-Chloro-quinazolin-4-yl)-(2-methoxy-phenyl)-methyl-amine

実験手順

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(2-methoxy-phenyl)-amine and methyl iodide by a procedure similar to Example 36 (72% yield). 1H NMR (CDCl3): 7.72 (d, J=8.1 Hz, 1H), 7.54 (ddd, J=8.4, 6.6 and 1.5 Hz, 1H), 7.20 (dd, J=8.4 and 1.8 Hz, 1H), 6.87-7.04 (m, 4H), 3.67 (s, 3H), 3.56 (s, 3H).

出典と根拠

ORDレコード: ord-6d3a5db9f7d948c6a28e3d59e0f4e35d
出典データセット: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08309562B2

反応ノート

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