Pyridine → 2-Methyl-5-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carbonyl]-piperidin-3-yl}-benzonitrile

反応式

[CH3:1][c:2]1[c:3]([C:4](=[O:5])[NH2:6])[cH:7][c:8]([CH:11]2[CH2:12][N:13]([C:17](=[O:18])[c:19]3[c:20]([CH3:34])[n:21][c:22](-[c:24]4[cH:25][cH:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]4)[s:23]3)[CH2:14][CH2:15][CH2:16]2)[cH:9][cH:10]1.[CH3:54][CH2:55][O:56][CH2:57][CH3:58].[F:35][C:36]([F:37])([F:38])[C:39]([O:40][C:41](=[O:42])[C:43]([F:44])([F:45])[F:46])=[O:47].[cH:48]1[cH:49][cH:50][n:51][cH:52][cH:53]1>>[CH3:1][c:2]1[c:3]([C:4]#[N:6])[cH:7][c:8]([CH:11]2[CH2:12][N:13]([C:17](=[O:18])[c:19]3[c:20]([CH3:34])[n:21][c:22](-[c:24]4[cH:25][cH:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]4)[s:23]3)[CH2:14][CH2:15][CH2:16]2)[cH:9][cH:10]1