Thionyl Chloride → HCID 58566473、化合物

HRID 1876364ノート

反応式

HRID 1876364 の反応式
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[S:10][C:9]2[C:11]([CH2:15]O)=[CH:12][CH:13]=[CH:14][C:8]=2[CH:7]=1>ClCCl>[Cl:3][CH2:15][C:11]1[C:9]2[S:10][C:6]([CH3:5])=[CH:7][C:8]=2[CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 58566649HCID 58566649、化合物

生成物 1

HCID 58566473HCID 58566473、化合物収率 67%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Thionyl chloride (0.415 mL, 5.69 mmol) was added slowly to an ice cold solution of the alcohol (510) (0.203 g, 1.14 mmol) in dichloromethane (6.0 mL). The reaction mixture was stirred and warmed to room temperature for 1 h. The resulting solution was quenched slowly with saturated sodium bicarbonate (10 mL) and extracted with dichloromethane, the organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to provide the intermediate 7-(chloromethyl)-2-methylbenzo[b]thiophene (511) (0.150 g, 67.0%) as a yellow oil.

後処理

  1. customThe resulting solution was quenched slowly with saturated sodium bicarbonate (10 mL)
  2. extractionextracted with dichloromethane
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-14b10aa089344246b9d3ef673c81a1a7
出典データセット
uspto-grants-2012_11
特許番号
US08309600B2

反応ノート

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