3-cyclopropyl-3-(4-{5-methoxy-2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile → 3-(4-{2-[(3-aminophenyl)amino]-5-methoxypyrimidin-4-yl}-1H-pyrazol-1-yl)-3-cyclopropylpropanenitrile

HRID 1876901ノート

反応式

HRID 1876901 の反応式
[CH:1]1([CH:4]([N:8]2[CH:12]=[C:11]([C:13]3[C:18]([O:19][CH3:20])=[CH:17][N:16]=[C:15]([NH:21][C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=4)[N:14]=3)[CH:10]=[N:9]2)[CH2:5][C:6]#[N:7])[CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[NH2:28][C:24]1[CH:23]=[C:22]([NH:21][C:15]2[N:14]=[C:13]([C:11]3[CH:10]=[N:9][N:8]([CH:4]([CH:1]4[CH2:3][CH2:2]4)[CH2:5][C:6]#[N:7])[CH:12]=3)[C:18]([O:19][CH3:20])=[CH:17][N:16]=2)[CH:27]=[CH:26][CH:25]=1

参加物

5

反応物 2

HCID 580145013-cyclopropyl-3-(4-{5-methoxy-2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 580145283-(4-{2-[(3-aminophenyl)amino]-5-methoxypyrimidin-4-yl}-1H-pyrazol-1-yl)-3-cyclopropylpropanenitrile

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 3-cyclopropyl-3-(4-{5-methoxy-2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile (from example 321, 0.010 g, 0.000025 mol) in 2 mL of MeOH was hydrogenated in the presence of 10% Pd/C, under balloon pressure of hydrogen, for 2 h. After filtering off the catalyst, the filtrate was evaporated to dryness to provide the desired product as a racemic mixture (8 mg, 86.39%). LCMS (M+H) 376.1.

後処理

  1. filtrationAfter filtering off the catalyst
  2. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-a122926773af43de8521c74475b77b11
出典データセット
uspto-grants-2012_11
特許番号
US08309718B2

反応ノート

読み込み中…