(2,4-Dichlorophenyl)boronic acid → Methyl 5-(2,4-dichlorophenyl)-2-methyl-3-furoate

反応式

Br[C:2]1[O:6][C:5]([CH3:7])=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1.[Cl:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1B(O)O>>[Cl:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[C:2]1[O:6][C:5]([CH3:7])=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1

参加物

反応物 2

HCID 2734659(2,4-Dichlorophenyl)boronic acid

HCID 15534190Methyl 5-bromo-2-methylfuran-3-carboxylate

生成物 1

HCID 68514435Methyl 5-(2,4-dichlorophenyl)-2-methyl-3-furoate収率 54%

実験手順

An operation similar to that in Example 49 (2) was performed using methyl 5-bromo-2-methyl-3-furoate (3.3 g) and 2,4-dichlorophenylboronic acid (3.4 g) to give the title compound (2.3 g, 54%) as a yellow crystal.

出典と根拠

ORDレコード: ord-45891623dc0f40a39a4f542f3e57787f
出典データセット: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08309580B2

反応ノート

読み込み中…