Thionyl Chloride → 4-[chloro(2-methyl-5-phenylfuran-3-yl)methyl]tetrahydro-2H-pyran

HRID 1877037

反応式

HRID 1877037 の反応式
[CH3:1][C:2]1[O:3][C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][C:6]=1[CH:7]([CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)O.S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[Cl:23][CH:7]([C:6]1[CH:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[O:3][C:2]=1[CH3:1])[CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 68514112(2-methyl-5-phenylfuran-3-yl)(tetrahydro-2H-pyran-4-yl)methanol

生成物 1

HCID 685124234-[chloro(2-methyl-5-phenylfuran-3-yl)methyl]tetrahydro-2H-pyran収率 100%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of (2-methyl-5-phenylfuran-3-yl) (tetrahydro-2H-pyran-4-yl)methanol (1.8 g) in toluene (20 mL) was added thionyl chloride (1.4 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to give the title compound (1.9 g, 100%) as an oil.

後処理

  1. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-0e72f28db2894c088dc58f41dc2592a1
出典データセット
uspto-grants-2012_11
特許番号
US08309580B2

関連ノート

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