Water → Chenodeoxycholate Propyl Gallate

HRID 1877749

反応式

HRID 1877749 の反応式
[CH3:1][C@@H:2]([C@@H:8]1[C@@:12]2([CH3:28])[CH2:13][CH2:14][C@@H:15]3[C@@:20]4([CH3:26])[CH2:21][CH2:22][C@@H:23]([OH:25])[CH2:24][C@H:19]4[CH2:18][C@@H:17]([OH:27])[C@H:16]3[C@@H:11]2[CH2:10][CH2:9]1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:29]([O:40][CH2:41][CH2:42][CH3:43])(=[O:39])[C:30]1[CH:38]=[C:36]([OH:37])[C:34]([OH:35])=[C:32]([OH:33])[CH:31]=1.O>[OH-].[Na+]>[CH3:1][C@@H:2]([C@@H:8]1[C@@:12]2([CH3:28])[CH2:13][CH2:14][C@@H:15]3[C@@:20]4([CH3:26])[CH2:21][CH2:22][C@@H:23]([OH:25])[CH2:24][C@H:19]4[CH2:18][C@@H:17]([OH:27])[C@H:16]3[C@@H:11]2[CH2:10][CH2:9]1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:29]([O:40][CH2:41][CH2:42][CH3:43])(=[O:39])[C:30]1[CH:31]=[C:32]([OH:33])[C:34]([OH:35])=[C:36]([OH:37])[CH:38]=1

参加物

5

反応物 3

HCID 962WaterHCID 4947Propyl GallateHCID 10133Chenodeoxycholic Acid

生成物 1

HCID 131730067Chenodeoxycholate Propyl Gallate

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒2 回

実験手順

1 g of chenodeoxycholic acid is dissolved in 3.4 g of sodium hydroxide solution (30 mg/ml) with warming. The solution is brought to room temperature and adjusted to pH 7.85 by addition of further sodium hydroxide solution. 500 mg of propyl gallate is then added and dissolved by shaking at room temperature. The pH is adjusted to 7.45, and 56.25 mg of recombinant human insulin is added with stirring at 37° C. After all the solid has dissolved, the solution is made up to a total weight of 8 g with distilled water, frozen and lyophilised overnight to give a dry crystalline powder.

後処理

  1. temperaturewith warming
  2. customis brought to room temperature
  3. dissolutiondissolved
  4. additionis added
  5. stirringwith stirring at 37° C
  6. dissolutionAfter all the solid has dissolved
  7. temperaturefrozen
  8. customto give a dry crystalline powder

出典と根拠

ORDレコード
ord-588aa8e911784ae3a1e218bbb47189cf
出典データセット
uspto-grants-2012_11
特許番号
US08314058B2

関連ノート

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