Potassium Hydroxide → HCID 137068883、化合物
反応式
Cl.[NH2:2][OH:3].[OH-].[K+].[Cl:6][CH2:7][C:8]([NH:10][C:11]1[CH:12]=[N:13][C:14]([C:17]#[N:18])=[CH:15][CH:16]=1)=[O:9]>CO>[Cl:6][CH2:7][C:8]([NH:10][C:11]1[CH:12]=[N:13][C:14]([C:17](=[N:2][OH:3])[NH2:18])=[CH:15][CH:16]=1)=[O:9]参加物
5
実験手順
Hydroxylamine hydrochloride (0.16 g, 2.3 mmol) was added to a solution of potassium hydroxide (0.152 g, 2.3 mmol) in methanol and the mixture was stirred for 30 minutes and filtered. To the filtrate, compound of example 3 (0.3 g, 1.53 mmol) was added and reaction mixture was refluxed for 4 hours. After completion of reaction the mixture was cooled, concentrated and triturated with diethyl ether to obtain the title compound.
後処理
- filtrationfiltered
- customreaction mixture
- temperaturewas refluxed for 4 hours
- customAfter completion of reaction the mixture
- temperaturewas cooled
- concentrationconcentrated
- customtriturated with diethyl ether
出典と根拠
- ORDレコード
- ord-c404df0c24084c34841264fc935271b0
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08314103B2
反応ノート
読み込み中…