Piperazin-4-ylacetophenone → 1-[(6-Chloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(4-acetylphenyl)piperazine

HRID 1878136

反応式

HRID 1878136 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15](=[O:19])OCC)=[N:5]2.[C:20]([C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)(=[O:22])[CH3:21]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15]([N:32]1[CH2:31][CH2:30][N:29]([C:26]3[CH:25]=[CH:24][C:23]([C:20](=[O:22])[CH3:21])=[CH:28][CH:27]=3)[CH2:34][CH2:33]1)=[O:19])=[N:5]2

参加物

3

反応物 2

HCID 97269Piperazin-4-ylacetophenoneHCID 66918182Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate

生成物 1

HCID 669180141-[(6-Chloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(4-acetylphenyl)piperazine収率 85%

実験手順

Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate and 1-(4-acetylphenyl)piperazine were reacted by the same way with the example 22 to obtain the titled compound (yield, 85%). 1H NMR (300 MHz, CDCl3): δ 2.54 (s, 3H), 3.50 (s, 4H), 3.80 (s, 3H), 4.14 (s, 4H), 6.89 (d, J=7.7 Hz, 2H), 7.44 (s, 1H), 7.66 (s, 1H), 7.79 (s, 1H), 7.79 (s, 1H), 7.91 (d, J=7.7 Hz, 2H).

出典と根拠

ORDレコード
ord-69760adc7a7f4eb1a0eb154c35da048a
出典データセット
uspto-grants-2012_11
特許番号
US08314100B2

関連ノート

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